粘附分子β_1整合素在伤口愈合中表达的研究

【英文篇名】Study on the expression of integrin α_5,β_1during wound healing

【作者中文名】陈敏亮; 牛星焘; 林子豪; 李健宁; 秦泽莲; 薛宏宇; 朱晓海;

【作者英文名】CHEN Minliang; NIU Xingtao; LIN Zihao; et al. Department of Plastic and Reconstructive Surgery; Third School of Clinical Medicine; Beijing Medical University; Beijing 100083; China;

【作者单位】北京医科大学附属第三临床医学院整形外科; 上海第二军医大学附属长征医院整形外科; 上海第二军医大学附属长;

【文献出处】中华烧伤杂志, Chinese Journal of Burns, 编辑部邮箱 2000年 02期

期刊荣誉：

【关键词】伤口愈合; 整合素; 成纤维细胞; 原位杂交;

【英文关键词】Wound healing; Integrin; Fibroblast（s）; In situ hybridizatiX;

【摘要】目的研究伤口愈合过程中 ,粘附分子整合素家族在介导细胞与细胞外基质间的主要作用。方法运用原位杂交技术对 12例中厚取皮区创面成纤维细胞表面整合素α5、β1亚基mRNA表达进行了检测。结果中厚取皮供区整合素α5、β1染色阳性的真皮成纤维细胞密度较正常皮肤显著增高。结论上述结果提示创面成纤维细胞整合素α5、β1表达增高可能参与伤口愈合时高产量胶原成纤维细胞亚群的激活

【英文摘要】Objective To explore the potential role of integrin family in mediating the interaction between cells and extracellular matrix(ECM) during wound healing. Methods In situ hybridization technique was employed in the determination of the expression of the mRNA of the subunits of integrinα 5,β 1 on the surface of fibroblasts in the donor sites of partial thickness skin of 12 burned patients. Results Evidently more integrin α 5,β 1 positive staining fibroblasts were found in the donor site than in norma…